APRIL 16-18, 2019

BOSTON, MA USA

The 6th Annual Translational Microbiome Conference is Coming Back to Boston in April 2020. 

Please check back in the coming weeks for additional details.

The Official Blog of the Annual Translational Microbiome Conference

The official blog of the Annual Translational Microbiome Conference provides readers with information, insight and analysis regarding the microbiome.

Tailoring Microbiome Interventions: The Intersection of Precision Medicine and the Microbiome

By Carrie Brodmerkel, Senior Director, Systems Pharmacology & Biomarkers, Janssen R&D

The microbiome gets a lot of press these days, from leading scientific journals such as Science publishing a special issue “Microbiota at Work” in April, 1 to articles about fecal microbiome transplants in major newspapers like the Washington Post.2 Many articles tout the need for a healthy gut microbiome and that the diversity of the gut microbiome is what maintains not just gut health but overall health. But for all of the hype, what do we really know about what a healthy microbiome looks like? What do we really know about the impact of the microbiome on health and disease? Is there a universal definition of a healthy microbiome or is it more likely that the each person has his or her own unique healthy gut microbiome?

A study published in 2015 in Science Advances studied the fecal, oral and skin microbiome of an Amerindian tribe, the Yanomami, who were completely isolated from the Western world.3 The researchers found that the Yanomami had the highest levels of human microbial diversity ever reported. They also don’t suffer from Western diseases like cardiovascular and metabolic disease or autoimmune and inflammatory diseases. Does this infer that gut microbial diversity equates to better health and less disease? That has not yet been proven and it may be that the microbiome in this tribe works in conjunction with a far different lifestyle and lack of chemical and pharmaceutical impacts and interventions to support a lack of disease. Still it drives the question of whether personalized cocktails of microbes will be needed to achieve optimal gut health for a given individual or group of individuals with similar microbiomes?

This collision of microbiome research and the precision medicine space, and the potential need for patient selection and personalization of microbiome therapies, will play out as microbial based therapeutics begin to hit the clinic. Evidence supporting this need already exists from fecal microbial transplant studies in C. difficile and inflammatory bowel disease where the response rates in an unselected population of patients leaves opportunity for improvement. Efforts to understand the functional effects of the microbes that inhabit the human gut and determining which promote health and which promote disease will be essential in unraveling the microbial communities necessary to promote health at the population or cohort level.

Hear more about Janssen’s efforts to define patient stratification strategies and personalized medicine in the age of microbial-based therapeutics at Arrowhead’s 3rd Annual Translational Microbiome Conference, being held April 12-13, 2017 in Boston, MA. For more information, visit: http://www.microbiomeconference.com

1 Science Magazine April 2016 http://science.sciencemag.org/content/352/6285

2 https://www.washingtonpost.com/news/speaking-of-science/wp/2016/04/28/scientists-think-theyve-found-the-secret-to-better-poop-transplants/?utm_term=.91f00d298c91

3 http://advances.sciencemag.org/content/1/3/e1500183.

Interestingly, despite their isolation and no known exposure to antibiotics, it was found that the tribe harbored bacteria that carried functional antibiotic resistance genes, including those that confer resistance to synthetic antibiotics and are syntenic with mobilization elements.

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About Us

Our events give attendees a conference experience that encompasses learning, networking and professional growth. We strive to facilitate connections. At our events, attendees, speakers, sponsors and exhibitors have opportunities to network and then to utilize those connections to further their professional goals. At Arrowhead Publishers, our focus is on bringing life sciences industry professionals together to help move research forward. Learn more about us at www.arrowheadpublishers.com.

Contact Us

Arrowhead Publishers & Conferences
PO Box 96
7730 Laredo Drive, #96
Chanhassen, MN 55317
866-945-0263
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NEW EVENT JUST ANNOUNCED

The Microbiome-Vaccine Summit: Microbiome-Mediated Immunity and the Future of Vaccines

Dates and Location: September 2019 | London, United Kingdom

Microbes in the gut have been found to exert profound control over the immune system. The role of the microbiome in modulating the immune response has already been substantially researched with numerous correlations between the microbiome’s immune effects and disease hypothesized and being explored. One exciting area of inquiry is the potential for the microbiome to play a substantial role in vaccine response. This area of exploration includes:

♦ Its potential to change how patients respond to checkpoint inhibition therapy for metastatic melanoma
♦ Correlations between the efficacy of the rotavirus and geographic differences in the gut biome
♦ How the antibiotic-mediated dysbiotic gut microbiome may actually mount a strong immune response to the seasonal flu vaccine
♦ And the gut-lung axis, or the role of the microbiome in the meteoric rise of asthma
♦ And even the possibility of explaining why some children experience adverse reactions to vaccinations, and why our current vaccine protocol starting within 12 hours of birth does not properly factor gut microbiota as crucial to immune response.

An extension of the highly successful Arrowhead Translational Microbiome Conference held every April in Boston, join us for this first event in our Translational Microbiome Spotlight series, where we bring together industry and academic experts considering the interface between the microbiome and vaccines in a one day, highly interactive roundtable forum.

CLICK HERE to request more information. If you are interested in speaking or sponsorship opportunities, please email This email address is being protected from spambots. You need JavaScript enabled to view it..