Clinical Metagenomics to Address Changing Landscape of Infectious Diseases – Challenges and Opportunities
Clinical metagenomics appears to be paramount to 21st century approaches to rapid microbial detection and precise sub-typing of pathogens, characterizing the microbiome in health and disease, profiling polymicrobial communities, and/or co-infections. It offers a unique opportunity to investigate the complete genetic make-up of microbial pathogens to understand evolution, pathogenesis, clonal transmission, and provides opportunity to comprehensively profile hundreds of species in a sample and even discover entirely new infectious agents. However, there are many challenges associated with pre-sequencing, sequencing, and post-sequencing steps in metagenomics workflow because each directly affects the accuracy and precision and the ability to make an actionable and timely diagnosis.
The workshop will offer the entire clinical metagenomics workflow, its use for broad range pathogen detection, identification of community resistome, analytical sensitivity and specificity, and interpretation of data in clinical perspective.
WORKSHOP LEADER: Nur A. Hasan, Ph.D., MBA, Adjunct Associate Professor, Center for Bioinformatics and Computational Biology, University of Maryland Institute of Advanced Computer Studies, Vice President, CosmosID Inc.